Page Comparison

Review: Identify tangible activities for this working group

Identify use cases / challenges in lab interoperability.

1. D-dimer (DIMER - Overview: D-Dimer, Plasma (mayocliniclabs.com))

Use case review

1. D-dimer re-reviewed by Dr. Dash

2. Andrea Pitkus described how LIDR is envisioned to be used. Taking POC use cases as a next step. What constitutes uniqueness (unique ID for LIDR - might have multiple rows with same LOINC code but different LIDR IDs). Different specimens, reference ranges, methodologies may result in different LIDR ID. No resource in government or healthcare organizations to go through package inserts and determine equivalency. National level - registry needed for coordination. Some discussion of private vs public dissemination of data from IVD manufacturers.

3. https://www.mayocliniclabs.com/test-catalog/overview/602174
   Mayo has a few different d-dimer orders, so would be good to connect which one is in each report
   https://www.mayocliniclabs.com/test-catalog/overview/40936
   https://ltd.aruplab.com/Tests/Pub/0030057

4. Standards required for harmonization:

   1. Source of information (Duke, Mayo, ARUP, UNMC, etc)

   2. LOINC code

   3. Reference range (what “type” being specified in the result?)

      1. the standard distribution for “normal” population

      2. expected value for the specific patient, given demographics, history, disease conditions

   4. Methodology

   5. Instrument w/ test kit specific to the test (as specified by manufacturer)

   6. Some type of harmonization status (LIDR “ID” as described above)

   7. Preferred display name (as specified in LOINC code?) - TruLab’s focus

5. Will adapt above list into a spreadsheet for comparison of results

Next steps

1. Pull package inserts from D-dimers

2. Sample report, HL7 interface message, Instrument name, model, “ID” would be ideal to compare

3. AST (AST - Overview: Aspartate Aminotransferase (AST) (GOT), Serum (mayocliniclabs.com))

4. Urine culture and susceptibility testing (DUHS Electronic Test Catalog (duke.edu))